This clinical and radiological analysis of EGFR revealed certain associations between the EGFR wild status and EGFR exon 19 mutation (the female gender, pleural retraction, a small lesion diameter, the absence of emphysema and the absence of fibrosis), and a scoring system based on this multivariable analysis may suggest a new proposal to predict the EGFR mutation status. The gene discussed is EGFR; the disease is pulmonary emphysema.