SLC26A4 and Pendred syndrome: Pendred syndrome (PDS) is classically described as bilateral sensorineural hearing loss and thyroid enlargement, and PDS is caused by mutations of SLC26A4 gene, disease may occurs at any age from birth to adolescence, inducement including colds, fever, mild craniocerebral trauma, barotrauma, or other causes of increased intracranial pressure.[40] We have informed the parents of the subject with homozygous mutation in c.IVS7-2A > G, to closely observe the child's behavior and its response to sound.