The haplotype was actually associated with ACPA(+)RA in unconditioned analysis (P = 0.0078, OR = 1.24, 95% CI 1.06–1.44), or when conditioned on DRβ chain amino acid residues (Padjusted = 4.11X10-5, ORadjusted 1.47, 95%CI 1.22–1.77). The gene discussed is PRTN3; the disease is rheumatoid arthritis.