PRTN3 and rheumatoid arthritis: On the other hand, some haplotypes including DPB1*02:01 were associated with the ACPA(+)RA susceptibility (DRB1*04:05-DPB1*02:01; Permutation P <0.0001, DRB1*09:01-DPB1*02:01; Permutation P = 0.0048, S3 Table) or the protection (DRB1*04:06-DPB1*02:01; Permutation P = 0.0149, DRB1*08:02-DPB1*02:01; Permutation P<0.0001, DRB1*13:02-DPB1*02:01; Permutation P = 0.0015, DRB1*15:01-DPB1*02:01; Permutation P = 0.0208, S3 Table), suggesting the influences of DRB1 alleles on the effects of DPB1*02:01.