On the other hand, the OR for DRB1*04:05 in ACPA(+)RA patients with DPB1*02:01 was 4.21 (P = 3.71X10-12, S2 Table), and the OR for DRB1*04:05 in ACPA(+)RA patients without DPB1*02:01 was 3.33 (P = 7.58X10-15, S2 Table). This evidence concerns the gene PRTN3 and rheumatoid arthritis.