When conditioned on DRB1*04:05, the significant association of DPB1*02:01 with the susceptibility of ACPA(+)RA was observed (Padjusted = 0.0073, ORadjusted 1.29, 95%CI 1.07–1.56, Table 3). This evidence concerns the gene HLA-DPB1 and rheumatoid arthritis.