MTHFD2 and neoplasm: Our previously generated transcriptomic data [35] (GSE30784) on tumor tissues of 115 OCC patients and 45 normal oral mucosa from controls (42 OCC and 19 controls from that study were also in the current study) showed that the transcript levels from OCC tissues for the mitochondrial SHMT2 and MTHFD2 for glycine synthesis were significantly higher in cases than in controls, suggesting there was increased glycine synthesis in the OCC tumor cells to meet the increasing demand for nucleotide synthesis in the rapidly proliferating cells.