IGHE and mastocytosis: Symptomatic allergic patients to any kind of allergen were found to be positive to Anisakis specific IgE detection between 0.0% in children with mastocytosis (González de Olano 2007)[56] to 81.3% among adults with shellfish allergy (Pascual 1996) [44]; diagnostic bands at Immunoblot were visualized in 15–56% of cases (Caballero 2012)[31] (Montoro 1997)[50].