The current diagnostic algorithm of Anisakis-related allergy has been based upon suggestive anamnesis (appearance of symptoms few hours after raw fish intake) along with positive skin prick testing, enzyme-linked immunosorbant assay (ELISA), ImmunoCAP or immunoblotting determination of antigen-specific IgE and exclusion of fish allergy, but the high number of false positives due to cross-reactivities with numerous panallergens has underlined the need to improve the diagnostic approach [14–17]. The gene discussed is IGHE; the disease is allergic disease.