IGHE and urticaria: As for IgE detection, the largest Japanese study among 2,108 sera of urticaria or food allergy patients revealed 29.8% seroprevalence with a positivity threshold set at >0.7 kU/L, showing that patients suffering from type I allergic symptoms following ingestion of Anisakis parasitized fishes are more often sensitized to Anisakis specific allergen than to allergens of the seafood per se [20].