CC-220 is a significantly more potent IKZF1 and IKZF3 degrader than IMiD drugs (Matyskiela et al., 2018) (Nakayama et al., 2017) (Schafer et al., 2018), and it is currently in clinical trials for relapsed/refractory multiple myeloma and systemic lupus erythematosus. The gene discussed is IKZF3; the disease is plasma cell myeloma.