UBE2G1 loss also conferred resistance to CC-885 in OCI-AML2, U937, MOLM-13, and MV4-11 AML cells (Figure 6—figure supplement 1A–D), as well as 293 T cells, and this defect could be rescued by UBE2G1 wild-type but not C90S mutant (Figure 6—figure supplement 1E). The gene discussed is UBE2G1; the disease is acute myeloid leukemia.