UBE2G1 and cancer: The myeloma cell line SKMM-2, which lost both copies of the UBE2G1 gene (based on gene copy number characterization in Cancer Cell Line Encyclopedia), and has undetectable UBE2G1 protein expression (Figure 6B), was derived from a human myeloma patient who never received any prior treatment with IMiD drugs (Eton et al., 1989), warranting the further clinical evaluation of UBE2G1 activity in myeloma patients.