The myeloma cell line SKMM-2, which lost both copies of the UBE2G1 gene (based on gene copy number characterization in Cancer Cell Line Encyclopedia), and has undetectable UBE2G1 protein expression (Figure 6B), was derived from a human myeloma patient who never received any prior treatment with IMiD drugs (Eton et al., 1989), warranting the further clinical evaluation of UBE2G1 activity in myeloma patients. This evidence concerns the gene UBE2G1 and plasma cell myeloma.