UBE2G1 loss also reduced the degradation of GSPT1 induced by CC-885 in myeloma cell lines OPM2, DF15 and MM1S (Figure 3B, and Figure 3—figure supplement 1C,D), AML cell lines OCI-AML2, U937, MOLM-13 and MV4-11 (Figure 3—figure supplement 1E–H), as well as 293T human embryonic kidney cells (Figure 3—figure supplement 1I). Here, UBE2G1 is linked to acute myeloid leukemia.