For instance, we found that Fgfr2+/P253R Apert syndrome mice presented postnatal limb malformations involving the shape, length and volume of many bones of the forelimb, including the scapula, humerus, ulna, radius, metacarpals and phalanges (Table 1 and Figure 1). The gene discussed is FGFR2; the disease is Apert syndrome.