Deric M. Park and colleagues reported that CNS hemangioblastomas resected from VHL patients express several mesodermal markers including brachyury, stem cell leukemia (SCL) and fetal liver kinase 1 (FLK-1), which is consistent with the embryonically derived hemangioblasts [4]. The gene discussed is KDR; the disease is von Hippel-Lindau disease.