Indeed, overexpressed MANF has anti-apoptotic effect on the sympathetic and sensory neurons in vitro, and infused MANF protein protects the cerebral cortex in rat model of cerebral ischemia (Airavaara et al., 2010; Hellman et al., 2011; Matlik et al., 2015). The gene discussed is MANF; the disease is Cerebral ischemia.