Specifically, the selected human cancer cell lines were A2780 and A2780cisR (ovarian carcinoma cisplatin sensitive and resistant, respectively), MCF7 (breast carcinoma), A549 (lung carcinoma) as well as against HCT116 p53 +/+ and –/– (colon carcinoma p53 expressing and knock-out, respectively). The gene discussed is TP53; the disease is cancer.