For example, on one hand, it has been reported that hsa-miR-494-3p in human glioblastoma cells is up-regulated, which plays a key role in proliferation and migration of tumor cells via directly targeting PTEN, thereby resulting in the subsequent activation of the PI3K/Akt signaling pathway (Li et al., 2015). This evidence concerns the gene AKT1 and glioblastoma.