Data obtained from xenotumor or syngeneic immunocompetent murine tumor model revealed that both HLA-G1 or HLA-G5 expression promoted tumor development by impairment of innate and adaptive immune responses but favoring the immune suppressive cells such as CD11b+Gr1+ myeloid-derived suppressor cells (MDSC) expansion (3, 4). Here, ITGAM is linked to neoplasm.