IL6 and neoplasm: However, MDSCs expand under inflammatory conditions (52); the latter would allow us to propose that the increase in proinflammatory cytokines in healthy animals, (Figure 5I) as well as the significant increase in IL-6 in tumor-bearing mice and mice pretreated with P2Et (Figure 4) could act in concert to favor the deviation of the immune response toward immunosuppression and be translated into MDSC proliferation and recruitment, as has been suggested in other models (53).