Interestingly, a significant increase in the serum concentrations of TNF and IL-6 was found in the P2Et/P2Et groups compared with the other groups in both tumor models (Figures 4A,B), while in the P2Et/P2Et-treated B16 tumors, the serum concentrations of both IL-17 and IL-4 were significantly decreased (Figure 4A). Here, IL6 is linked to neoplasm.