BRCA genes, involved in DNA repair through HR after DSBs, are altered in sporadic and hereditary breast cancer; notably, in sporadic tumors BRCA1 mutations are rare (<5%) while ~10% of TNBC patients present germline mutations in BRCA1/2 which increase breast cancer risk about 60–70% (61, 62). The gene discussed is BRCA1; the disease is Hereditary breast cancer.