ADH5 and hepatocellular carcinoma: In this scenario, it has been reported that GSNOR-ablated (GSNOR-KO) mice show predilection to hepatocellular carcinoma (HCC) in association with S-nitrosylation and proteasomal degradation of the DNA damage repair enzyme O6-alkylguanine-DNA alkyltransferase (AGT) (29).