Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) regulates endothelial glycolysis and proliferation through the transcriptional regulation of PFKFB3, VEGFA, FOXO1, and MYC (155), with a positive correlation occurring between Nrf2, HIF-1α, and PFKFB3 expression in breast cancer cells, and cancer patients with high PFKFB3 expression showing poorer overall survival (156). Here, PFKFB3 is linked to breast cancer.