In hepatocellular carcinoma, high expression of metastasis-associated in colon cancer protein 1 (MACC1), a key regulator of the hepatocyte growth factor (HGF)/c-Met pathway, has been noted to correlate with the high expression of PFKFB2, this correlation being associated to TNM stage (classification of malignant tumors), overall survival and Edmondson-Steier classification (98). This evidence concerns the gene HGF and hepatocellular carcinoma.