MTOR and acute myeloid leukemia: In acute myeloid leukemia (AML), mTOR-mediated up-regulation of PFKFB3 is essential for cell survival, as mTORC1 up-regulates PFKFB3 in a HIF1α-dependent manner, and PFKFB3 silencing suppresses glycolysis and cell proliferation and activates apoptosis (147).