In a previous study, Ladoire et al examined changes in the levels of CD8+ TILs and FOXP3+ TILs after NAC in 56 patients with breast cancer and reported that a high rate of change in the CFR was associated with pCR.20 Miyashita et al also analysed 78 patients with TNBC and reported that high rates of change in the level of CD8+ TILs and the CFR were significantly correlated with good RFS and OS.15 However, there have been few studies stratifying by intrinsic subtype of breast cancer. Here, CD8A is linked to breast cancer.