However, based on the detailed subclassification of TILs as CD8+ TILs or FOXP3+ TILs, studies evaluating the prognostic significance of CD8+ TILs or FOXP3+ TILs or the CFR in the intrinsic molecular subtypes of breast cancer have shown conflicting results.15 17 34–40 One possible explanation consistent with these discrepant findings is that HRBC is also considered to be associated with some kind of immunity. This evidence concerns the gene CD8A and breast carcinoma.