TFPI2 and lung carcinoma: Moreover, Liu et al. also revealed that celecoxib, which was reported to induce promoter demethylation and reactivate expression of some metastasis-suppressor genes in lung cancer cells, could demethylate the methylation status of TFPI2 in vivo and up-regulate the gene expression as well as inducing the apoptosis of cancer cells (Liu et al., 2016).