Evidence suggests that a subset of anti-DNA antibodies derived from mouse models of SLE enter a variety of living cells (14–17, 38–43); several molecules, including calreticulin, myosin 1, and equilibrative nucleoside salvage transporter (ENT) act as cell surface receptors for internalization of some anti-DNA antibodies, although there is little direct evidence that they are endocytic receptors. The gene discussed is CALR; the disease is systemic lupus erythematosus.