Additionally, Savenije et al. have reported that SNPs of IL1RAP and TRAF6, a downstream molecule of the IL-33-ST2 pathway, are associated with a phenotype of intermediate-onset wheeze, which is closely associated with sensitization (71), suggesting that polymorphisms of genes involved in IL-33-ST2 axis are associated with onset of asthma in childhood. This evidence concerns the gene IL1RL1 and asthma.