On the other hand, Rigas et al. have shown that iTregs attenuate IL-33-induced airway hyperreactivity by inhibiting IL-5 and IL-13 production from ILC2s and that the interaction of inducible T-cell costimulator ligand (ICOSL) on ILC2s with ICOS on Tregs is required for Treg-mediated suppression of ILC2 function (68). Here, ICOSLG is linked to Irritability.