A recent study on bone marrow lympho-myeloid malfunction in obesity questioned the role of fetuin-A as a physical adapter between TLR4 and dietary saturated fats (49) and earlier studies showed that LPS-free fetuin-A is anti-inflammatory (21) and protects against vascular smooth muscle calcification (50). The gene discussed is AHSG; the disease is obesity due to melanocortin 4 receptor deficiency.