LAMP1 and neoplasm: To date, two approaches are widely applied for the detection and isolation of tumor-specific cytotoxic T lymphocytes: The first is based on the assessment of specific T cells functions, such as cytokine (typically IFN-γ) production (16) or activation-induced phenotypical modifications, such as cell surface expression of CD107a (LAMP-1) and / or CD137 (4-1BB) (17).