Importantly, several immunodeficiency syndromes (signal transducer and activator of transcription 3 [STAT3] deficiency, dedicator of cytokinesis 8 [DOCK8] deficiency, lipopolysaccharide-responsive-beige-like-anchor [LRBA] deficiency, Wiskott-Aldrich syndrome [WAS], and immune dysregulation, polyendocrinopathy, enteropathy, X-linked [IPEX] syndrome) present in childhood with atopy, elevated IgE and peripheral blood eosinophilia (27). The gene discussed is IGHE; the disease is Wiskott-Aldrich syndrome.