In fact, in a large prospective study with more than 330 pemphigus patients, only 4% of all pemphigus sera and 2.7% of PV and PF sera exhibited anti-desmocollin reactivity, while 98% of sera contained anti-Dsg3 and/or anti-Dsg1 IgG (52). Here, DSG1 is linked to pemphigus.