EP300 and infectious disease: Zheng et al. (2017) had researched the Kac level of pyruvate carboxylase and citrate synthase which were the key enzyme of TCA cycle were up-regulated proteins by the stress caused by patulin. They also found that ROS accumulation increase the expression levels of oxidoreductase to maintain the balance of redox state and to reduce the patulin toxicity in R. mucilaginosa. Huang et al. (2018) found that the most downregulated crotonylome alterations under p300 deficiency concern components of the nonsense-mediated decay, infectious disease, and viral/eukaryotic translation pathways.