Using a mouse model, this team showed that there was differential expression of certain gene pathways involved in embryonic organ development, pattern formation, branching morphogenesis, wingless/Int, and inflammation in vitamin D deficient mice, and included genes upregulated in individuals with asthma (e.g., matrix metallo-peptidase 9, NF-κ light polypeptide gene enhancer in B cells inhibitor, an epidermal growth factor receptor and E1A binding protein p300) (35). This evidence concerns the gene EP300 and asthma.