LAMB2 and Stroke: Clinically, BBB disruption leads to the development of hemorrhagic transformation that is associated with worse stroke outcome (20), and MMPs have been identified to play a key role in this process, degrading all components of the ECM including laminin, collagen and fibronectin, and the endothelial junction proteins claudin-5, occluding, and zona occludens (ZO)-1 (21).