To determine wherther the antdepressant-like role of H2S involves in the change of hippocampal autophagy in CRS-exposed rats, the effects of H2S on the number of autophagosomes and the expression of beclin1 as well as P62 in the hippocampus of CRS-exposed rats were detected. The gene discussed is SQSTM1; the disease is congenital rubella syndrome.