RLN2 and cardiovascular disorder: Since serelaxin (RLX030) represents the recombinant form of human relaxin-2, which shows quite reliable therapies in cardiovascular diseases (Papadopoulos et al., 2013; Parikh et al., 2013; Teerlink et al., 2013), we are aimed to identify the function and mechanisms of RXFP1signaling pathways utilized by human relaxins in the vasculature.