Although most studies have focused on the role of Slc26a9 in CF-related disease onset, we anticipate that Slc26a9 may also be involved in the pathogenesis of some unreported diseases, such as duodenal ulcers, Type 2 diabetes and hypertension, based on functional analysis (Amlal et al., 2013; Liu et al., 2015; Li et al., 2016). The gene discussed is SLC26A9; the disease is cystic fibrosis.