Many studies demonstrated the functions of WXKL on arrhythmia via regulating calcium channels, reducing the ICaL, preventing the occurring of EAD and DAD via acting on CaMKII signaling pathway (Chen et al., 2013a; Xing et al., 2013; Xue et al., 2013; Hou et al., 2016; Luo et al., 2017; Yang et al., 2017a) (Figure 5B). This evidence concerns the gene CAMK2G and cardiac arrhythmia.