The NaV1.7 expression in the CNS is responsible for anosmia and hyposmia, always linked to painless phenotypes, and epilepsy (presence of different variants in patients showing seizures and Dravet syndrome, and of two SCN9A mutations related to epilepsy phenotype), as well as to autism spectrum disorder (Dib-Hajj et al., 2013; Mulley et al., 2013; Rubinstein et al., 2018; Yang C. et al., 2018). Here, SCN9A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.