SCN8A and cancer: NaV1.6, encoded by the SCN8A gene, is a TTX-sensitive fast-activating and inactivating NaV channel expressed in the PNS (DRG neurons, nodes of Ranvier of motoneurons, Schwann cells), in the CNS (Purkinje, pyramidal and granule neurons, nodes of Ranvier and initial segment of axons, astrocytes, microglia) and in non-neuronal tissues such as cancer cells, endothelial cells, fibroblasts, keratinocytes and macrophages (Trimmer and Rhodes, 2004; Black and Waxman, 2013; Israel et al., 2017).