The important function of NaV1.1 in the CNS is highlighted by more than 500 mutations in its coding sequence that cause epileptic syndromes (Febrile Seizure, Generalized Epilepsy with Febrile Seizures +, and Severe Myoclonic Epilepsy of Infancy also known as Dravet syndrome) (Catterall et al., 2010). This evidence concerns the gene SCN1A and Dravet syndrome.