Motilin receptor agonistsErythromycin•Antibiotic drug used at lower doses to treat patients with gastroparesis and delayed gastric emptying12•Activates motilin receptors in enteric nervous system (prokinetic activity) and vagus13, 14, 15•Low doses may have anti-emetic activity; high doses cause emesis15•Limited by potential to exacerbate bacterial resistance, prolong cardiac QTc interval, and interact with cytochrome P450 CYP 3A412•The selective motilin agonist camicinal shown to promote gastric emptying and facilitate oral drug delivery in patients with Parkinson's disease16. The gene discussed is MLN; the disease is gastroparesis.