Since Nrf2 pathway plays a critical role in inflammation, Nrf2 activators has become a potential therapeutic strategy for numerous disorders (Crunkhorn, 2012), such as inflammatory disorders (Kim et al., 2010), cardiovascular diseases (Li et al., 2009), neurodegenerative diseases (Joshi and Johnson, 2012), cancer (Sporn and Liby, 2012), type 2 diabetes (Chartoumpekis and Kensler, 2013), chronic kidney disease (Ruiz et al., 2013) and multiple sclerosis (Gold et al., 2012). Here, NFE2L2 is linked to chronic kidney disease.