↓ cell viability, better efficacy than temozolomide at equimolar dosesdecreased tumor volume in mice without toxicity decreased orthotopic U87MG xenografts growth in nude mice in magnetic resonance imagingcrosses blood-brain barrier induced apoptotic death by modulating the protein expression of several apoptosis regulators (caspases, Bcl2 family members, and survivin)induced ER stress (increased GRP78 and calpain, and decreased calnexin and IRE1α expression)enhanced free intra-cellular calcium, and damaged cellular organization in GBM cells. This evidence concerns the gene HSPA5 and neoplasm.