Furthermore, chymase inhibition or deletion is able to reduce the infarct size in other models of heart failure, such as ischemia-reperfusion in the swine (Oyamada et al., 2011) or the mouse (Tejada et al., 2016); this may be due to reduced inflammation-induced cardiomyocyte death when chymase activity is suppressed. The gene discussed is CMA1; the disease is heart failure.