In the context of epilepsy, the targeting of PV interneurons may also be more preferable because there are reports that SST interneurons become depleted (Robbins et al., 1991), whereas PV interneurons survive in epileptic animals (Sloviter, 1991; Sloviter et al., 2003) and epilepsy patients (Sloviter et al., 1991). The gene discussed is SST; the disease is epilepsy.