Moreover, functional studies showed that DISC1 contributes to the etiopathology of mental illness, including regulating neural progenitor proliferation, neurite outgrowth, neuronal migration, synapse formation, neurogenesis and cAMP signaling (Lipina et al., 2012; Wen et al., 2014; Meng et al., 2016). Here, DISC1 is linked to psychiatric disorder.