EGFR and central nervous system cancer: ErbB and its ligand epidermal growth factor (EGF) are reported to participate in both glioma development and schizophrenia neuropathology (Berezowska and Schlegel, 2011; Sotoyama et al., 2011; Iwakura and Nawa, 2013; Brocard et al., 2015), so antipsychotic drug targeting the EGF/ErbBs signaling pathway can affect the tumorigenesis of glioma in persons with schizophrenia.