For example, inhibition of HIF-1α and VEGF reduced HT in the ischemic brain which was induced by acute hyperglycemia (Chen et al., 2010; Zhang et al., 2016) and inhibition of HIF-1α-VEGF signaling reduced BBB damage in rat neonatal stroke model (Mu et al., 2003). This evidence concerns the gene VEGFA and Hyperglycemia.