NLRP3 and Huntington disease: For the treatment of Huntington’s disease, although not much studies are available for the exploration of the therapeutic roles targeting on the NLRP3 inflammasome, there is one study demonstrating that pharmacological inhibition of the ATP-sensitive homomeric P2X7R contributes to the alleviation of Huntington’s disease through the suppression of the NLRP3 inflammasome activation (Sperlagh and Illes, 2014).