For example, it was reported that the cryopyrin-associated periodic fever syndrome (CAPS), a group of rarely diagnosed hereditary autoimmune diseases including Muckle-Wells syndrome and familial cold auto-inflammatory diseases, was mainly led to by the gain-of-function mutations of NLRP3 genes, which resulted in the overwhelming production and secretion of IL-1β and IL-18 (Kuemmerle-Deschner et al., 2017; Landmann and Walker, 2017). Here, NLRP3 is linked to cryopyrin-associated periodic syndrome.