NLRP3 and intracerebral hemorrhage: For the treatment of hemorrhagic stroke, it was previously demonstrated that blue brilliant G (BBG), a selective P2X7R inhibitor, contributed to the alleviation of the intracerebral hemorrhage-induced inflammatory injury in rat models through the inhibition of the NLRP3 inflammasome activation as well as attenuation of NADPH oxidase 2 (NOX2) and inducible nitric oxide synthase (iNOS) production (Feng et al., 2015).