NLRP3 and depressive disorder: Besides, it was recently reported that electro-acupuncture, one of the popular techniques of traditional Chinese medicine, contributed to the alleviation of the chronic unpredictable stress-induced depression and anxiety-like behaviors through the inhibition of the NLRP3 inflammasome activation, which was mediated by reversing the increase of P2X7R (Yue et al., 2018).