Besides, the activation of the NLRP3 inflammasome also serves as a vital factor for the onset and development of neurodegenerative diseases (Ahmed et al., 2017; Fu et al., 2017; Li et al., 2017; Sarkar et al., 2017; Wu et al., 2017; Aminzadeh et al., 2018; Bai et al., 2018; Gong et al., 2018; Qi et al., 2018). This evidence concerns the gene NLRP3 and neurodegenerative disease.