However, there were also studies demonstrating the limitation of the application of interferon-β in the treatment of the multiple sclerosis or EAE, showing that interferon-β therapy was effective against multiple sclerosis or EAE only in the NLRP3 inflammasome-dependent EAE (Inoue et al., 2012; Inoue et al., 2016). Here, NLRP3 is linked to multiple sclerosis.