NLRP3 and ischemic stroke: For the treatment of ischemic stroke, it was reported that pretreatment of minocycline, a tetracycline antibiotic, significantly prevented the activation of microglia through the inhibition of the NLRP3 inflammasome in the two steps of activation, thus improving neurological disorder, reducing infarct volume and alleviating cerebral edema (Lu et al., 2016).