AVPR2 and Parkinson disease: For instance, expression of NDI1 was sufficient to functionally replace complex 1 in cell culture (Yagi et al., 2006) and, moreover, extend lifespan and modulate energy metabolism of flies (Bahadorani et al., 2010; Sanz et al., 2010) as well as counteract detrimental effects of a Parkinson’s disease mouse model (Barber-Singh et al., 2009).