The discovery of a distinct protein (HTT) at the heart of this neurodegenerative disease also sparked the development of genetic models in various vertebrate (rhesus monkey, sheep, Tibetan miniature pig, rodents, zebrafish), invertebrate (Drosophila melanogaster, Caenorhabditis elegans), and unicellular (S. cerevisiae) organisms (Mason and Giorgini, 2011; Xi et al., 2011; Morton and Howland, 2013; Pouladi et al., 2013). The gene discussed is HTT; the disease is neurodegenerative disease.