GRIN2B and schizophrenia: In clinical studies, GluN2B antagonists exacerbate the schizophrenia-like symptoms in both healthy people and patients (Moghaddam and Javitt, 2012), while antipsychotic drug olanzapine can activate GluN2B via phosphorylation of the GluN2B at Y1472 (Zhang et al., 2016).