DICER1 and amyotrophic lateral sclerosis: The association we describe between mitochondria, Dicer and miR-124 in the mSOD1 ALS model suggests that this association is essential for fine-tuning local protein synthesis in the axon, an ability that may be lost in the early stages of the disease, thus contributing to the progressive nature of axonal degeneration and further strengthening the importance of local protein synthesis to synapse maintenance and axonal stability in ALS.