Atherosclerosis is an inflammatory/lipid-based disease, and the NLRP3 inflammasome has been considered as a link between lipid metabolism and inflammation because crystalline cholesterol and oxidized low-density lipoprotein (oxLDL), two abundant components in atherosclerotic plaques, activate the NLRP3 inflammasome (Hoseini et al., 2018). Here, NLRP3 is linked to atherosclerosis.