Nevertheless, seen the impressive histological/molecular results we obtained, we expected an even higher lifespan increase: however, the SMA pathogenesis is very complex and surely other pathways leading to MN death are implicated and can trigger the neurodegeneration (as for example the autophagic pathway or the crosstalk between Rho and ERK kinases, whose dysfunctions are well documented in SMA; Hensel et al., 2017, and Piras and Boido, 2018, respectively). This evidence concerns the gene RHO and proximal spinal muscular atrophy.