Moreover, duplications of SHANK3 have also been found in patients with Asperger’s syndrome, attention-deficit hyperactivity disorder (ADHD) (Moessner et al., 2007), bipolar disorder (Han et al., 2013), and SCZ (Failla et al., 2007), and the transgenic mice that mildly overexpress Shank3 proteins (∼50%) display manic-like hyperkinetic behaviors and spontaneous seizures (Han et al., 2013; Choi and Han, 2015; Lee et al., 2018). This evidence concerns the gene SHANK3 and bipolar disorder.