Considering the associations of GPR85/SREB2 with ASDs and SCZ (Matsumoto et al., 2008; Chen et al., 2012; Radulescu et al., 2013; Fujita-Jimbo et al., 2015), more investigations about the functional relationship between Shank3 and GPR85 would provide information on the detailed mechanisms of activity-dependent synaptic regulation and their potential implications in multiple brain disorders. This evidence concerns the gene SHANK3 and brain disorder.