SHANK3 and autism: The other was from the PFC of juvenile (5- to 6-week-old) Shank3+/ΔC mice (Qin et al., 2018), which are heterozygous mice for C-terminal exon 21 deletion of Shank3. The Shank3+/ΔC mice show a 50–70% reduction of Shank3 proteins in the PFC and display several autism-like behaviors, including social preference deficits and repetitive behaviors, together with molecular and functional changes of excitatory synapses in the PFC (Duffney et al., 2015).