The prevention of changes to TF accessibility with BEZ235 + JQ1 combinations was consistent with reduced expression of TF-activity-related genesets as measured by GSEA: decreases in AP1, SNAIL, GATA3, NFKB, and TCF motif accessibility in BEZ235 + JQ1-treated cells relative to BEZ235-treated cells correlates with de-enrichment of genesets related to FRA154, SNAI155 and GATA356 overexpression in mammary cancer cells, NFkB activity-related genesets, and a WNT activity signature57 (Fig. 6e, Supplementary Data 3 “TF and C6 3day BEZJQ1vsDMSO”). Here, HNF4A is linked to breast cancer.