We identified a predicted damaging KDR missense variant p.(Ala1030Thr) (CADD = 35, SIFT = 0, PolyPhen2 = 1), located in the protein kinase domain adjacent to the catalytic residues Asp1028 and Arg1032 (ref. 11) in a mother and daughter, both with TOF and pulmonary atresia. This evidence concerns the gene WEE1 and Pulmonary artery atresia.