FLT4 and coronary artery disorder: A multisite collaborative study using exome sequencing recently identified FLT4 loss-of-function variants in 2.3% of children with TOF.4 Exome sequencing also revealed another FLT4 frameshift deletion in a TOF patient.5 As part of a genome sequencing study of the underlying genetic causes in adults with CHD, predominantly TOF, from a single site, we investigated rare and predicted damaging variants in FLT4 and other vascular endothelial growth factor (VEGF)-related genes.