Finally, SST2 expression in normal exocrine pancreatic tissue is progressively lost during pancreatic ductal adenocarcinoma progression (Buscail et al., 1996; Laklai et al., 2009), which participates in tumor aggression, as demonstrated in mouse models of pancreatic cancer combined with SST2 KO mice (Chalabi-Dchar et al., 2015). The gene discussed is SSTR2; the disease is familial pancreatic carcinoma.