Although GH-secreting adenoma SST2 expression may be less abundant following pretreatment with SRIF analogs (Casar-Borota et al., 2013), this does not appear to result in drug resistance in acromegaly and TSH-secreting adenomas, whereas tachyphylaxis has been observed in patients with NETs (Toumpanakis and Caplin, 2013). This evidence concerns the gene CORT and acromegaly.