Depending on phosphatase activity, SST2 activation also triggers apoptosis in endogenous SST2-expressing pituitary somatotroph tumor cells (Ben-Shlomo and Melmed, 2010), and also in pancreatic cancer cells engineered to express this receptor, where apoptosis is further stimulated by treatment with death ligands (Ben-Shlomo and Melmed, 2010). Here, CORT is linked to familial pancreatic carcinoma.