The porcine Sstr1 gene promoter showed positive regulation by cAMP (through a CREBBP1 binding site) (Gahete et al., 2014), consistent with the cAMP-mediated upregulation of SST1 mRNA in rat pituitary primary cultures induced by GHRH treatment (Park et al., 2000), and in pituitary adenomas expressing a mutated Gαs (gsp oncogene) that constitutively activates the cAMP pathway (Kim et al., 2005). Here, SST is linked to pituitary gland adenoma.