Such SST specificities were also observed in pituitary tumor cells, where, in contrast to SST2, SST1 fails to stimulate phosphoinositide-specific phospholipase C (PLC) activity or PLC-dependent release of Ca2+ from intracellular stores (Chen et al., 1997), but transduces inhibition of phospholipase A2 activity and arachidonic acid release, similar to SST2 (Cervia et al., 2002). The gene discussed is HSPG2; the disease is pituitary tumor.