Agonist-dependent phosphorylation of the four threonine residues was also documented in rat pituitary tumor cells (GH3) transiently transfected with rat SST2, rat pancreatic insulinoma β-cells (INS1 cells), which endogenously express SST2, and rat pancreas in vivo (Poll et al., 2010). The gene discussed is CORT; the disease is pituitary tumor.