Finally, the SST1 gene promoter contains two CpG islands (Redmann et al., 2007), putatively involved in head and neck squamous cell carcinoma tumorigenesis, where hypermethylation of the SSTR1, but also of SRIF, gene has been correlated with reduced disease-free survival (Misawa et al., 2015). The gene discussed is SSTR1; the disease is head and neck squamous cell carcinoma.