Cultured adenoma cells from the fully responsive patients responded equally to treatment with either octreotide or the SST2+5 biselective analog, BIM23244; however, octreotide produced only a partial response in cells from partially responsive patients, whereas BIM-23244 produced a greatly enhanced response, similar to that observed in the adenoma cells from fully responsive patients (Saveanu et al., 2001). Here, CORT is linked to adenoma.