Through screening in rodents, analogs were identified with potent GH-suppressing activity with acceptably low insulin-suppressing activity (Bauer et al., 1982; Heiman et al., 1987), including the two SRIF analogs still most widely used clinically for treatment of acromegaly and NETs, octreotide (Sandostatin) and lanreotide (Somatuline) (Fig. 23; Table 9). The gene discussed is INS; the disease is acromegaly.