In contrast to other SSTs, a number of studies have identified single-nucleotide polymorphisms in the human SST5 gene that may imply potential pathophysiological functions in pancreatic NETs and other cancers (Li et al., 2011; Zhou et al., 2011, 2012), bipolar affective disorder (Nyegaard et al., 2002), acromegaly (Lania et al., 2008; Ciganoka et al., 2011), prostate cancer (Hormaechea-Agulla et al., 2017), and in the regulation of circulating IGF-1 and IGFBP3 in prostate and breast cancer (Gu et al., 2010). This evidence concerns the gene SSTR5 and acromegaly.