SST1 immunoreactivity is observed both at the membrane and in the cytoplasm in primary and heterologous cell models (Gahete et al., 2014), and in paraffin-embedded sections of diverse human tumor tissues, in contrast to SST2, which is predominantly membrane-associated (Hofland et al., 1999; Lupp et al., 2013). Here, SSTR2 is linked to neoplasm.