PKM and cancer: Among them, we recovered well-known markers and related genes of cancer stem cells, including activated leukocyte cell adhesion molecule (ALCAM) [20–40], pyruvate kinase (PKM) [41], fatty acid synthase (FASN) [42], vascular endothelial growth factor (VEGFA) [43–45], a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) [46], B cell lymphoma 2 like 1 (BCL2L1) [47–50], connective tissue growth factor (CTGF) [51], catenin beta 1 (CTNNB1) [52, 53], PDZ and LIM domain protein 7 (PDLIM7) [54–59], steroid sulfatase (STS) [60–64], and SET nuclear proto-oncogene (SET) [65–67].